The Mechanics of Stress Response

by Dr. Chris Hardy on July 21, 2016

Chris Hardy Navy Diving School

This is the first in a series of articles developed from Dr. Chris Hardy’s live presentation at Dragon Door’s Inaugural Health and Strength Conference.

I was 23 years old and had graduated from one of the toughest schools in the military. It was designed to mentally and physically beat you down. After 5-6 months, I came out thinking I was super human—of course at 23 we think that anyway. We were crushed with physical training twice a day with academics in between. But, when I graduated, I really didn’t know anything about training others. I thought training and getting better was all about getting beat down as hard as possible. But, I didn’t know that I would soon be facing a different challenge.

When I arrived at my new unit as the new guy, and they put me in charge of their training. They were all seasoned deep sea divers—a very physically demanding job, probably one of the hardest on the planet. Training military divers is like training athletes. They’re a very resilient, self-selected group. My dive school class started with 35, and 13 graduated. So the people who graduate are pretty hard to break. They put me in charge of their training, and over the next two years I developed my own routine of mashing them as hard as I could, because that’s what they wanted.

Overweight General Population ClientDuring that same time, I got interested in medicine. I didn’t always want to be a doctor, but at 25, I decided I needed a change of pace. I went to college and thought that since I was already a trainer, I would train people while I went to college.

I was used to dealing with military deep sea divers, and all I was working with people who have diseases and were out of shape. I didn’t know how to deal with any of these conditions and it blew my mind. I decided to learn more and started getting certifications. Over the next 20 years, I tried to hone my training craft and I even became a doctor along the way!

I wanted to know how to get results for these people without breaking them in the process. I couldn’t train them like Navy divers, because they wouldn’t come back and I would certainly break them. In 22 years as a trainer, and 12 years as a physician I don’t have all the answers, but I have developed a framework.

Your clients want results from you, but what’s your responsibility to them? Safety, or as in medical terminology, “do no harm”. We want them to achieve their goals, but we want them to do it safely. Sometimes you have to save your clients from themselves, because they think they know what they want but you really need to educate them. We also have a popular culture that creates more challenges for us in the perception of what exercise and weight loss should be like.

Quote Primum Non NocereTV shows like The Biggest Loser and other transformation programs are what our clients are seeing. They’re getting the message that every workout needs to be a beat-down, and if you’ve watched that show or others like it, there’s a calorically restricted diet. And that’s what our clients think will get them results. How many of you have new clients come to you expecting that kind of workout—and who aren’t happy when they don’t get it? Or maybe you aren’t getting clients because they are too scared to even come to your gym.

We have a huge opportunity. As a good coach, we need to educate our clients on why the beat down workouts are not a good approach.

What is Coaching?

Coaching is an art with a scientific foundation. If you’re a professional, you have the art down, so now we will look at our foundation to answer some key questions:

  • How can I optimally dose the training on any given day for my client?
  • How can I prevent overdosing but still training the client hard enough so that they achieve their goals?

We aren’t letting our clients off the hook, this is the holy grail of training.

When I look at any problem, I want to go back to underlying foundations—that’s how I wrote Strong Medicine, and it’s how I approach medicine. I look at the foundations of the problem in the first place—it’s what I call first principles. Next, we can build a conceptual framework to answer the questions from the bottom up.

Before we could build a space shuttle, we first had to figure out how to make fire. In building up our conceptual framework, let’s begin by defining exercise. Exercise is a form of stress. What is stress? , Hans Selye defined stress as an engineering term as the amount of force per unit area. Now we say, “I’m under a lot of stress” or, “I am stressed out”.

Stress Examples

Anything that triggers the stress response is a stressor—including exercise. Getting attacked by a bear, traffic, or doing dumbbell presses are all sources of stress. External stress examples include food, water, activity, your work environment, traffic. Internal stress can come from diseases—it all activates in the brain.

Is Stress Good or Bad?

Both, it depends. Short term stress is necessary for survival and if you want to make any gains in the gym. Marty Gallagher will tell you that, you can’t have sub-optimal stress if you want to make gains in the gym. But the chronic stress in an over-trained endurance runner or someone who is just completely burned out at their job is not good.

These chronic stresses actually lead to physical changes in the brain and nervous system, and over-activates our stress response. You could argue that the modern environment has toxic levels of stress and that our physiology is at odds with our modern environment. We are probably not wired to handle what we’re dealing with on a daily basis. We can easily recover from short term acute stress, and most of the time we’re not under it. But, many people are now under constant chronic stress, including your clients. And, you can’t train your clients as if they live in a vacuum.

BrainThe brain is command central for the stress response. It receives, evaluates, and responds to stress in our environment from all sources. It is very important to understand that stress is everything the brain perceives as stress—whether or not the issue is a threat to life or limb. If your brain perceives something as stress, then you will trigger the stress response.

It is especially true in modern society. If your boss is a real jerk and you’re under stress at work, that same fight or flight response will be active as if you were running from a bear—maybe not to the same degree, but it will still be active.

We have fast and slow pathways. Simply put, the hypothalamus is a very small part of the brain but it’s actually central to the stress response. When the brain perceives something threatening—if someone scares you—then you get that fluttering heart, “all-jacked-up” feeling. That’s the fast pathway, and it’s direct to the adrenal glands. It dumps adrenaline, epinephrine, and norepinephrine. Afterwards, about twenty minutes later, the slow pathway through the pituitary gland and down to the adrenals is active. It’s a hormonal system that secretes cortisol which helps you recover from the stress. For the purposes of this post, that’s all you need to know about neuro-anatomy.

Those of you who have also trained in Chinese Medicine or follow Taoist philosophy know that the Yin/Yang concept works very well to describe the autonomic nervous system. (Autonomic just means that I don’t have to think about it for it to happen—I don’t have to think to raise my heart rate or to breathe at night.) The autonomic nervous system has two branches, sympathetic (fight or flight), and parasympathetic (rest and recovery). The “fight or flight” system is actually the most inflammatory response in the body. The parasympathetic system is the opposite. Typically, the parasympathetic system should be dominant most of the time, and the sympathetic should only be active when we need to use it for a “flight or fight” response or during exercise. The sympathetic system is used in response to stress—but it should be used minimally.

Autonomic Nervous System Diagram

The parasympathetic system is dominant for the recovery to all of the exercise you’re doing (and that your clients are doing). It’s also when that anabolic response to exercise occurs. But, if the sympathetic system is on all the time—as it is for many of our clients and ourselves—in the long term it will lead to muscle-wasting and chronic diseases.

How the Brain Controls Stress Response

Three main parts of the brain control the stress response to perceived threats. The prefrontal cortex (we also use it to maintain attention) right behind the forehead determines if something is truly a threat using higher reasoning. Our memory center, the hippocampus also helps us determine if something is threatening or not. The prefrontal cortex and hippocampus can override the threat response together if they have determined something has been seen or experienced before and is probably not threatening. The amygdala is the brain structure which drives the threat response, it responds to learned fear and the emotional reaction of stress. If I got an electric shock every time someone rang a bell or hit a gong, then pretty soon every time I would hear a sound like that, I would have a severe stress response. That’s what the amygdala does.

Normally, the hippocampus and prefrontal cortex inhibit the stress response, and the amygdala will activate it. It’s a three prong connection, and the brain will perform normally if the parasympathetic system is dominant most of the time. For example, if you see long cylindrical object across your path while walking in the woods, the prefrontal cortex will pay attention to it, the hippocampus will respond that it recognizes that it’s probably a stick, and will generally keep the brain from triggering the stress response.

Brain Diagram Stress StructuresBut over time, a brain will change in response to chronic stress. The word neuroplasticity means that the brain can functionally and structurally change. We used to think that psychological stress was “all in your head”, but in fact the brain can change its structure and how it functions—and you can actually be lose neurons. A person who is stressed out or depressed over a long term will have a physically different brain—the hippocampus will shrink under chronic stress.

Epigenetics is how the genes in our DNA are expressed. In Strong Medicine, I used this example: genes are a recipe that says I need four eggs to make a cake. So, if I do a mutation and use five eggs, then that’s a mutation to the genes. Epigenetics doesn’t change the genes, it just tells me how many “cakes” (if any) will be made from the recipe. When someone is under constant stress, everything is involved including hormone pathways. Everything involved with the stress response will be amped up and producing more products for the stress response.

So, someone under chronic stress will respond differently to exercise. If their stress response is overactive, it won’t take much to activate it, and they will have a harder time recovering from exercise because the sympathetic nervous system will be more dominant. If they are already in such a fight or flight state, it will take longer for the parasympathetic nervous system to allow for recovery. Normally the brain would use these mechanisms for survival, not a chronic perceived stress.

Stress Examples 2

Going back to our example with the stick across a path in the woods, if the brain is under chronic stress it will become more animal-like. The structure has changed and when someone with a chronically stressed brain sees something lying across the path, and the hippocampus memory has shrunk, you might jump straight to the conclusion that the object is a snake and trigger the stress response. The chronically stressed brain responds and reacts as opposed to focusing, maintaining attention, and drawing on previous memories.

How does all of this relate to fitness and training? As trainers—and I’ve done this myself—we often focus only on physical stresses. But, we aren’t training in a vacuum, so we must consider our environments. Our clients are faced with many sources of stress outside exercise stress, and we want to train them effectively. Allostasis is a broad concept that basically means “achieving stability through change”. While homeostasis means that a specific equilibrium is maintained, allostasis changes the point we come back to maintain that equilibrium. The stress response is part of this process. If you are trying to achieve stability with the environment, then we are also trying to achieve stability with anything perceived as threatening, challenging, or dangerous, right?

Allostasis is the mechanism responsible for adaptation to any challenge, exercise, or social, psychological activity. We need some psychological stress to become resilient, but too much of it and we can become depressed and anxious. Nutrition is similar, we need to be adequately nourished but not overly so, since the body will adapt to over-nutrition, and we see that all the time. The same is also true for sleep—too little sleep and the body adapts with a stress response, and new science is showing that too much sleep is also bad.

As far as the brain is concerned, recovering from a training challenge with endorphins, and growth hormone building bigger muscles and more mitochondria is allostasis—the brain will think that you need to get stronger to survive that type of challenge/stress again. Allostasis brings you to a new set point as opposed to homeostasis taking you back to the same equilibrium. This is a relatively new concept. Total stress is also called the allostatic load—allostasis is the change, and allostatic load is everything that the brain perceives from the environment as stress.



The next post in this series will outline a visual representation of the Stress Cup and how to use it to optimize your training and client training programs.

Chris Hardy, D.O., M.P.H., CSCS, is the author of Strong Medicine: How to Conquer Chronic Disease and Achieve Your Full Genetic Potential. He is a public-health physician, personal trainer, mountain biker, rock climber and guitarist. His passion is communicating science-based lifestyle information and recommendations in an easy-to-understand manner to empower the public in the fight against preventable chronic disease.





Building Your Health Fortress, One Brick at a Time

by Dr. Chris Hardy on December 24, 2015

Health Fortress

The New Year is almost upon us and millions of people will be making resolutions to improve their health. Gym memberships are purchased, new diets are tried, and home exercise equipment is ordered. Unfortunately most of these resolutions are doomed to fail, often by the time March rolls around. The gym memberships go unused, the diets are not sustainable, and the exercise equipment becomes an expensive clothes hanger. The cycle will repeat the following New Year, with many of us starting over again, sometimes in worse health than the previous year. No long-term progress is ever made. Why do we set ourselves up for failure year after year?

The modern environment lays perpetual siege to the health of our body and mind. Fast food, nasty bosses, long work hours, financial worries, domestic conflicts, poor sleep, and pollutants/toxicants are part of the world in which we live. With these health-destroying enemies at our gates, we have to put in more effort than ever before to achieve and maintain optimum health. We have to build a health fortress to protect us from the modern environment.

The primary reason most resolutions go unrealized soon after they are made has less to do with the actual resolutions themselves and more to do with how they are implemented-the plan. Attempting to radically change your current lifestyle overnight is akin to building a huge wall with brick and stone and not using mortar. You can build an impressive wall quickly but it will soon crumble under the slightest outside pressure, certainly not siege-worthy.

An instant gratification mindset leads to this sad excuse for a wall.

An instant gratification mindset leads to this sad excuse for a wall.

To build an impregnable Health Fortress, each brick and stone has to be placed and then sealed with mortar for strength and resilience. This process takes time and effort, but the result is a structure that you can build on year after year, not a flimsy construct that has to be rebuilt from scratch every year.

Each brick/stone for your fortress is a small positive lifestyle change. Each change must be sealed in place with time as the mortar. When you can incorporate a small lifestyle change into your daily routine for at least 90 days, the chances of it sticking for life increases dramatically. This is the way you can slowly build each wall of your fortress, and the building process is sustainable.

There are hundreds of potential bricks (lifestyle changes) outlined in Strong Medicine. In the book, we call them defensive tactics. On New Years day, pick a couple of these that you think you need the most and incorporate them into your life for 3 months. By the time March rolls around, the new bricks are no longer changes but have become part of your wall, set in place and resilient. Then pick a couple more bricks and continue the process. Even if you just picked 2 changes every 3 months, by next New Year you will be well on your way to having an impressive wall. Instead of starting over again, you now have a structure on which to keep building. This is how a Health Fortress is made, and sustainable wellness is achieved.

Don’t fall into the New Year’s resolution trap. Start 2016 with a New Life Resolution and build your Health Fortress.

Strong Medicine Scroll


Chris Hardy, D.O., M.P.H., CSCS, is the author of Strong Medicine: How to Conquer Chronic Disease and Achieve Your Full Genetic Potential. He is a public-health physician, personal trainer, mountain biker, rock climber and guitarist. His passion is communicating science-based lifestyle information and recommendations in an easy-to-understand manner to empower the public in the fight against preventable chronic disease.


Journey to the Center of the Physiological Universe

December 2, 2015

“We here in the Western world are top-heavy. ‘Shoulders back! Chest out! Stomach in!’ Thus the center of gravity becomes elevated. In zazen, Zen training, the tanden (or hara) is the source and foundation of deep meditation. When moving, the tanden is the source of bodily strength. Abdominal breathing generates strength: we live  from this […]

Read the full article →

Don’t Fear the Sleeper!

November 12, 2015

Want to lose fat and gain muscle? Want to improve your cognitive ability and decrease reaction time? Want to increase your ability to heal from illness and injury? Want to do it without taking expensive supplements or complicated diets? Sure, everyone does! Then let me tell you a little secret: Sleep is one of the […]

Read the full article →

Folding Inner Space, Part III – Pure Awareness and Deep Athletics in Action

October 29, 2015

Mark Chaillet, world record holder, world champion: Mark is shown in 1980 deadlifting 800-pounds. He weighs 219 in the picture and is badly out of position, struggling to finish the lift. His shoulders have gotten in front of the bar during the upward pull and now, with legs already straightened; he must finish locking out […]

Read the full article →

Folding Inner Space, Part II – Cessation of Thought and Super-Human Effort

October 15, 2015

Hormonal Nitrous Oxide Body-shocking physical effort, maximum effort of a very specific type and kind births an exercised-induced altered state of pure awareness that elite athletes routinely experience, yet fail to identify.  Access to this exercise-induced zone of pure awareness can only be attained when the degree of difficulty is sufficient to cross a hormonal […]

Read the full article →

Folding Inner Space: Part I – Iron Zen: Exercise-Induced Altered States

October 1, 2015

Tibetan Lama Dungse Jampol is the son of a Tibetan meditation master. At a young age he asked his father to explain to him, “What is the nature of the mind?” and “What is ‘pure existence” and what is the meaning of “enlightenment?” His father sat down and said to the boy, “Come closer.” The […]

Read the full article →

Quieting the Mind-Monkeys

September 17, 2015

“This restless monkey, which is thought, has broken up this world and has made a frightful mess of this world, it has brought such misery, such agony. And, thought cannot solve this, however intelligent, however clever, however erudite, however capable of efficient thinking, it cannot, thought cannot possibly bring order out of this chaos. There […]

Read the full article →

The Stress Cup and Training

September 10, 2015

How full is your stress cup? For those that have not read the incredible book, Strong Medicine, the stress cup is a great way to view your overall stress levels. The cup can only hold so much before it overfills and starts to spill. If your cup is running over then you are not able […]

Read the full article →

East Meets West

September 3, 2015

I’ve been waiting a very long time to write this blog post. Something near and dear to me, the state of the medical situation not only in the United States but everywhere in the world should create concern for all of this planet’s inhabitants. The answers are out there. We have them all. Unfortunately, money […]

Read the full article →